Journal of Cardiovascular Computed Tomography
Volume 1, Issue 1 , Pages 38-39 , July 2007

Importance of the negative clinical trial: advancing the field through failure

  • Gilbert L. Raff, MD*

      Affiliations

    • Ministrelli Center For Advanced Cardiovascular Imaging, William Beaumont Hospital, 3601 13 Mille Road NE, Royal Oak, MI 48073, USA
    • ,
  • Allen J. Taylor, MD

      Affiliations

    • Cardiology Service, Walter Reed Army Medical Center, Washington, DC, USA

References 

  1. Huber S, Huber M, Dees D, Redmond FA, Wilson JM, Flamm SD. Usefulness of multislice spiral computed tomography coronary angiography in patients with acute chest pain in the emergency department. J Cardiovasc CT. 2007;1:29–37
  2. Goldstein JA, Gallagher MJ, O’Neill WW, Ross MA, O’Neil BJ, Raff GL. A randomized controlled trial of multi-slice coronary computed tomography for evaluation of acute chest pain. J Am Coll Cardiol. 2007;49:863–871
  3. Hoffmann U, Nagurney JT, Moselewski F, Pena A, Ferencik M, Chae CU, et al. Coronary multidetector computed tomography in the assessment of patients with acute chest pain. Circulation. 2006;114:2251–2260
  4. Olivetti L, Mazza G, Volpi D, Costa F, Ferrari O, Pirelli S. Multislice CT in emergency room management of patients with chest pain and medium-low probability of acute coronary syndrome. Radiol Med (Torino). 2006;111:1054–1063
  5. Sato Y, Matsumoto N, Ichikawa M, Kunimasa T, Iida K, Yoda S, et al. Efficacy of multislice computed tomography for the detection of acute coronary syndrome in the emergency department. Circ J. 2005;69:1047–1051
  6. Savino G, Herzog C, Costello P, Schoepf UJ. 64 slice cardiovascular CT in the emergency department: concepts and first experiences. Radiol Med (Torino). 2006;111:481–496
  7. Hamon M, Biondi-Zoccai GG, Malagutti P, Agostoni P, Morello R, Valgimigli M, et al. Diagnostic performance of multislice spiral computed tomography of coronary arteries as compared with conventional invasive coronary angiography: a meta-analysis. J Am Coll Cardiol. 2006;48:1896–1910
  8. Johnson TR, Nikolaou K, Wintersperger BJ, Leber AW, von Ziegler F, Rist C, et al. Dual-source CT cardiac imaging: initial experience. Eur Radiol. 2006;16:1409–1415
  9. Dewey M, Hoffmann H, Hamm B. Multislice CT coronary angiography: effect of sublingual nitroglycerine on the diameter of coronary arteries. Rofo. 2006;178:600–604

PII: S1934-5925(07)00014-7

doi: 10.1016/j.jcct.2007.04.012

Journal of Cardiovascular Computed Tomography
Volume 1, Issue 1 , Pages 38-39 , July 2007

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