Journal of Cardiovascular Computed Tomography
Volume 2, Issue 4 , Pages 234-242 , July 2008

Potential of dual-energy computed tomography to characterize atherosclerotic plaque: ex vivo assessment of human coronary arteries in comparison to histology

  • Mitya Barreto, MS

      Affiliations

    • Imaging Institute, Cardiovascular Imaging Lab, Cleveland Clinic, Desk Hb6, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    • Department of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH, USA
    • Lerner Research Institute, Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA
    • ,
  • Paul Schoenhagen, MD

      Affiliations

    • Imaging Institute, Cardiovascular Imaging Lab, Cleveland Clinic, Desk Hb6, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    • Department of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH, USA
    • Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA
    • ,
  • Anuja Nair, PhD

      Affiliations

    • Lerner Research Institute, Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA
    • Volcano Corporation, Cleveland, OH, USA
    • ,
  • Stacy Amatangelo, BS

      Affiliations

    • Volcano Corporation, Cleveland, OH, USA
    • ,
  • Margherita Milite, PhD

      Affiliations

    • Siemens Medical Solutions, Erlangen, Germany
    • ,
  • Nancy A. Obuchowski, PhD

      Affiliations

    • Imaging Institute, Cardiovascular Imaging Lab, Cleveland Clinic, Desk Hb6, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    • Lerner Research Institute, Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA
    • ,
  • Michael L. Lieber, MS

      Affiliations

    • Imaging Institute, Cardiovascular Imaging Lab, Cleveland Clinic, Desk Hb6, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    • Lerner Research Institute, Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA
    • ,
  • Sandra S. Halliburton, PhD

      Affiliations

    • Imaging Institute, Cardiovascular Imaging Lab, Cleveland Clinic, Desk Hb6, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    • Department of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH, USA
    • Lerner Research Institute, Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA
    • Corresponding Author InformationCorresponding author.

Received 27 March 2008 ,Accepted 24 May 2008.

References 

  1. Burke AP, Farb A, Malcom GT, Liang Y-h, Smialek J, Virmani R. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 1997;336:1276–1282
  2. Horiguchi J, Fugioka C, Kiguchi M, Shen Y, Althoff C, Yamamoto H, et al. Soft and intermediate plaques in coronary arteries: how accurately can we measure CT attenuation using 64-MDCT. Am J Cardiol. 2007;189:981–988
  3. Becker CR, Nikolaou K, Muders M. Ex vivo coronary atherosclerotic plaque characterisation with multi detector row CT. Eur Radiol. 2003;13:2094–2098
  4. Nikolaou K, Becker C, Muders M, Barbaryka G. Multidetector-row computed tomography and magnetic resonance imaging of atherosclerotic lesions in human ex vivo coronary arteries. Atherosclerosis. 2004;174:243–252
  5. Schroeder S, Kuettner A, Leitritz M, Janzen J, Kopp A, Herdeg C, et al. Reliability of differentiating human coronary plaque morphology using contrast-enhanced multislice spiral computed tomography: a comparison with histology. J Comput Assist Tomogr. 2004;28:449–454
  6. Cademartiri F, Mollet NR, Runza G, Bruining N, Hamers R, Somers P, et al. Influence of intracoronary attenuation on coronary plaque measurements using multislice computed tomography: observations in an ex vivo model of coronary computed tomography angiography. Eur Radiol. 2005;15:1426–1431
  7. Halliburton S, Schoenhagen P, Nair A, Stillman A, Lieber M, Tuzcu M, et al. Contrast enhancement of coronary atherosclerotic plaque: a high-resolution, multidetector-row computed tomography study of pressure-perfused, human ex-vivo coronary arteries. Coron Artery Dis. 2006;17:553–560
  8. Achenbach S, Moselewski F, Ropers D, Frencik M. Detection of calcified and noncalcified coronary atherosclerotic plaque by contrast enhanced submillimeter multidetector spiral computed tomography. Circulation. 2004;6:14–17
  9. Becker CR, Knez A, Ohnesorge B, Schoepf UJ, Reiser MF. Imaging of noncalcified coronary plaques using helical CT with retrospective ECG gating. AJR Am J Roentgenol. 2000;175:423–424
  10. Becker CR, Ohnesorge BM, Schoepf UJ, Reiser MF. Current development of cardiac imaging with multidetector-row CT. Eur J Radiol. 2000;36:97–103
  11. Komatsu S, Hirayama A, Omori Y, Ueda Y, Mizote I, Fujisawa Y, et al. Detection of coronary plaque by computed tomography with a novel plaque analysis system, ‘plaque map’, and comparison with intravascular ultrasound and angioscopy. Circulation. 2005;69:72–77
  12. Kopp AF, Schroeder S, Baumbach A, Kuettner A, Georg C, Ohnesorge B, et al. Non-invasive characterisation of coronary lesion morphology and composition by multislice CT: first results in comparison with intracoronary ultrasound. Eur Radiol. 2001;11:1607–1611
  13. Kunimasa T, Sato Y, Sugi K, Moroi M. Evaluation by multislice computed tomography of atherosclerotic coronary artery plaques in non-culprit remote coronary arteries of patients with acute coronary syndrome. Circ J. 2005;69:1346–1351
  14. Leber AW, Knez A, White CW, Becker A, von Ziegler F, Muehling O, et al. Composition of coronary atherosclerotic plaques in patients with acute myocardial infarction and stable angina pectoris determined by contrast-enhanced multislice computed tomography. Am J Cardiol. 2003;91:714–718
  15. Leber A, Knez A, Becker A, Becker C, Boekstegers P. Accuracy of multidetector spiral computed tomography in identifying and differentiating the composition of coronary atherosclerotic plaques. J Am Coll Cardiol. 2004;43:1241–1247
  16. Leber AW, Becker A, Knez A, von Ziegler F, Sirol M, Nikolaou K, et al. Accuracy of 64-slice computed tomography to classify and quantify plaque volumes in the proximal coronary system. J Am Coll Cardiol. 2006;47:672–677
  17. Schoenhagen P, Tuzcu EM, Stillman AE, Moliterno DJ, Halliburton SS, Kuzmiak SA, et al. Non-invasive assessment of plaque morphology and remodeling in mildly stenotic coronary segments: comparison of 16-slice computed tomography and intravascular ultrasound. Coron Artery Dis. 2003;14:459–462
  18. Schroeder S, Kopp A, Baumbach A, Meisner C, Kuettner A, Georg C, et al. Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography. J Am Coll Cardiol. 2001;37:1430–1435
  19. Pohle K, Achenbach S, MacNeill B, Ropers D, Ferencik M, Moselweski F, et al. Characterization of non-calcified coronary atherosclerotic plaque by multi-detector row CT: comparison to IVUS. Atherosclerosis. 2007;190:174–180
  20. Viles-Gonzalez JF, Poon M, Sanz J, Rius T, Nikolaou K, Fayad ZA, et al. In vivo 16-slice, multidetector-row computed tomography for the assessment of experimental atherosclerosis: comparison with magnetic resonance imaging and histopathology. Circulation. 2004;110:1467–1472
  21. Achenbach S, Ropers D, Kuettner A, Flohr T, Ohnesorge B, Bruder H, et al. Contrast-enhanced coronary artery visualization by dual-source computed tomography–initial experience. Eur J Radiol. 2006;57:331–335
  22. Alverez RE, Macovski A. Energy-selective reconstructions in x-ray computerized tomography. Phys Med Biol. 1976;21:733–744
  23. McCullough EC. Photon attenuation in computed Tomography. Med Phys. 1975;2:307–320
  24. Raptopoulos V, Karellas A, Bernstein J, Reale FR, Constantinou C, Zawacki JK. Value of dual-energy CT in differentiating focal fatty infiltration of the liver from low-density masses. Am J Roentgenol. 1991;157:721–725
  25. Nickoloff EL, Feldman F, Atherton JV. Bone mineral assessment: new dual-energy CT approach. Radiology. 1988;168:223–228
  26. Rutherford RA, Pullan BR, Isherwood I. Measurement of effective atomic number and electron density using an EMI scanner. Neuroradiology. 1976;11:15–21
  27. Mollet NR, Cademartiri F, Runza G. In vivo assessment of attenuation of different plaque tissue components using multislice CT coronary angiography. Circulation. 2004;110:e514
  28. Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1995;92:1355–1374
  29. Stary H, Chandler A, Glagov S, Guyton J, Insull W, Rosenfeld M, et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis (A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association). Circulation. 1994;89:2462–2478
  30. McCollough CH, Kantor B, Primak AN, Krauss B, Schmidt B, Flohr T, et al. Fast, dual-energy, multi-slice CT can discriminate Fe and Ca. Circulation. 2006;114:II_724-d-5
  31. Johnson TR, Krauss B, Sedlmair M, Grasruck M, Bruder H, Morhard D, et al. Material differentiation by dual energy CT: initial experience. Eur Radiol. 2007;17:1510–1517
  32. Engler P, Friedman WD. Review of dual-energy computed tomography techniques. Mater Eval. 1990;48:623–629
  33. Flohr TG, McCollough CH, Bruder H, Petersilka M, Gruber K, Süss C, et al. First performance evaluation of a dual-source CT (DSCT) system. Eur Radiol. 2006;16:256–268
  34. Hyafil F, Cornily J-C, Feig JE, Gordon R, Vucic E, Amirbekian V, et al. Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography. Nat Med. 2007;13:636–641
  35. Sirol M, Itskovich VV, Mani V, Aguinaldo JGS, Fallon JT, Misselwitz B, et al. Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance imaging. Circulation. 2004;109:2890–2896

 Conflict of interest: Margherita Milite is an employee of Siemens Medical Solutions. Sandra S. Halliburton receives research funding from Siemens Medical Solutions.

PII: S1934-5925(08)00318-3

doi: 10.1016/j.jcct.2008.05.146

Journal of Cardiovascular Computed Tomography
Volume 2, Issue 4 , Pages 234-242 , July 2008

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