Journal of Cardiovascular Computed Tomography
Volume 4, Issue 2 , Pages 119-126 , March 2010

Coronary distensibility index measured by computed tomography is associated with the severity of coronary artery disease

  • Naser Ahmadi, MD

      Affiliations

    • Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles (UCLA) Medical Center, 1124 W Carson Street, RB2, Torrance, CA 90502, USA
    • Corresponding Author InformationCorresponding author.
    • ,
  • David Shavelle, MD

      Affiliations

    • Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles (UCLA) Medical Center, 1124 W Carson Street, RB2, Torrance, CA 90502, USA
    • ,
  • Vahid Nabavi, MD

      Affiliations

    • Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles (UCLA) Medical Center, 1124 W Carson Street, RB2, Torrance, CA 90502, USA
    • ,
  • Fereshteh Hajsadeghi, MD

      Affiliations

    • Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles (UCLA) Medical Center, 1124 W Carson Street, RB2, Torrance, CA 90502, USA
    • ,
  • Shahin Moshrefi, BS

      Affiliations

    • Department of Cardiology, New York Medical Center, Valhalla, NY, USA
    • ,
  • Ferdinand Flores, BS

      Affiliations

    • Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles (UCLA) Medical Center, 1124 W Carson Street, RB2, Torrance, CA 90502, USA
    • ,
  • Shahdad Azmoon, MD

      Affiliations

    • Department of Cardiology, New York Medical Center, Valhalla, NY, USA
    • ,
  • Song S. Mao, MD

      Affiliations

    • Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles (UCLA) Medical Center, 1124 W Carson Street, RB2, Torrance, CA 90502, USA
    • ,
  • Ramin Ebrahimi, MD

      Affiliations

    • Greater Los Angeles Veterans Affairs Medical Center, UCLA, School of Medicine, Los Angeles, CA, USA
    • ,
  • Matthew Budoff, MD

      Affiliations

    • Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles (UCLA) Medical Center, 1124 W Carson Street, RB2, Torrance, CA 90502, USA

Received 18 August 2009 ,Accepted 2 January 2010.

References 

  1. Goode GK, Miller JP, Heagerty AM. Hyperlipidaemia, hypertension, and coronary heart disease. Lancet. 1995;345:362–364
  2. Drexler H. Endothelial dysfunction clinical implications. Prog Cardiovasc Dis. 1997;39:287–324
  3. Griendling KK, Ushio-Fukai M, Lassegue B, Alexander RW. Angiotensin II signaling in vascular smooth muscle. New concepts. Hypertension. 1997;29:366–373
  4. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med. 1992;326:242–250
  5. Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med. 1990;323:27–36
  6. Cox DA, Vita JA, Treasure CB, Fish RD, Alexander RW, Ganz P, et al. Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans. Circulation. 1989;80:458–465
  7. Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986;315:1046–1051
  8. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 2000;101:1899–1906
  9. Bank AJ, Wang H, Holte JE, Mullen K, Shammas R, Kubo SH. Contribution of collagen, elastin, and smooth muscle to in vivo human brachial artery wall stress and elastic modulus. Circulation. 1996;94:3263–3270
  10. Sudhir K, Mullen WL, Hausmann D, Fitzgerald PJ, Chou TM, Yock PG, et al. Contribution of endothelium-derived nitric oxide to coronary arterial distensibility an in vivo two-dimensional intravascular ultrasound study. Am Heart J. 1995;129:726–732
  11. Hironaka K, Yano M, Kohno M, Tanigawa T, Obayashi M, Konishi M, et al. In vivo aortic wall characteristics at the early stage of atherosclerosis in rabbits. Am J Physiol. 1997;273:H1142–H1147
  12. Nakatani S, Yamagishi M, Tamai J, Goto Y, Umeno T, Kawaguchi A, et al. Assessment of coronary artery distensibility by intravascular ultrasound. Application of simultaneous measurements of luminal area and pressure. Circulation. 1995;91:2904–2910
  13. Hanekamp CE, Koolen JJ, Pijls NH, Michels HR, Bonnier HJ. Comparison of quantitative coronary angiography, intravascular ultrasound, and coronary pressure measurement to assess optimum stent deployment. Circulation. 1999;99:1015–1021
  14. Tuzcu EM, Schoenhagen P. Atherosclerosis imaging intravascular ultrasound. Drugs. 2004;64(suppl):21–27
  15. Becker CR, Knez A, Jakobs TF, Aydemir S, Becker A, Schoepf UJ, et al. Detection and quantification of coronary artery calcification with electron-beam and conventional CT. Eur Radiol. 1999;9:620–624
  16. Cespedes I, Ophir J, Ponnekanti H, Maklad N. Elastography elasticity imaging using ultrasound with application to muscle and breast in vivo. Ultrason Imaging. 1993;15:73–88
  17. Lu B, Mao SS, Zhuang N, Bakhsheshi H, Yamamoto H, Takasu J, et al. Coronary artery motion during the cardiac cycle and optimal ECG triggering for coronary artery imaging. Invest Radiol. 2001;36:250–256
  18. Mao S, Lu B, Takasu J, Oudiz RJ, Budoff MJ. Measurement of the RT interval on ECG records during electron-beam CT. Acad Radiol. 2003;10:638–643
  19. McLeod AL, Newby DE, Northridge DB, Fox KA, Uren NG. Influence of differential vascular remodeling on the coronary vasomotor response. Cardiovasc Res. 2003;59:520–526
  20. Yamagishi M, Umeno T, Hongo Y, Tsutsui H, Goto Y, Nakatani S, et al. Intravascular ultrasonic evidence for importance of plaque distribution (eccentric vs circumferential) in determining distensibility of the left anterior descending artery. Am J Cardiol. 1997;79:1596–1600
  21. Camacho F, Avolio A, Lovell NH. Estimation of pressure pulse amplification between aorta and brachial artery using stepwise multiple regression models. Physiol Meas. 2004;25:879–889
  22. Lamia B, Teboul JL, Monnet X, Osman D, Maizel J, Richard C, et al. Contribution of arterial stiffness and stroke volume to peripheral pulse pressure in ICU patients an arterial tonometry study. Intensive Care Med. 2007;33:1931–1937
  23. Munir S, Guilcher A, Kamalesh T, Clapp B, Redwood S, Marber M, et al. Peripheral augmentation index defines the relationship between central and peripheral pulse pressure. Hypertension. 2008;51:112–118
  24. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;1:307–310
  25. van Popele NM, Grobbee DE, Bots ML, Asmar R, Topouchian J, Reneman RS, et al. Association between arterial stiffness and atherosclerosis the Rotterdam Study. Stroke. 2001;32:454–460
  26. Shimazu T, Hori M, Mishima M, Kitabatake A, Kodama K, Nanto S, et al. Clinical assessment of elastic properties of large coronary arteries pressure-diameter relationship and dynamic incremental elastic modulus. Int J Cardiol. 1986;13:27–45
  27. Newman CM, Maseri A, Hackett DR, el-Tamimi HM, Davies GJ. Response of angiographically normal and atherosclerotic left anterior descending coronary arteries to acetylcholine. Am J Cardiol. 1990;66:1070–1076
  28. Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance an integrated index of vascular function?. Circulation. 2002;106:2085–2090
  29. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension. 2001;37:1236–1241
  30. Oliver JJ, Webb DJ. Noninvasive assessment of arterial stiffness and risk of atherosclerotic events. Arterioscler Thromb Vasc Biol. 2003;23:554–566
  31. Haluska BA, Jeffries L, Carlier S, Marwick TH: Measurement of arterial distensibility and compliance to assess prognosis. Atherosclerosis. Published ahead of print on October 22, 2009, as DOI: 10.1016/j.atherosclerosis.2009.10.018.
  32. Shechter M, Issachar A, Marai I, Koren-Morag N, Freinark D, Shahar Y, et al. Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease. Int J Cardiol. 2009;134:52–58
  33. Papathanassiou K, Naka KK, Kazakos N, Kanioglou C, Makriyiannis D, Pappas K, et al. Pioglitazone vs glimepiride: differential effects on vascular endothelial function in patients with type 2 diabetes. Atherosclerosis. 2009;205:221–226
  34. Ostad MA, Eggeling S, Tschentscher P, Schwedhelm E, Boger R, Wenzel P, et al. Flow-mediated dilation in patients with coronary artery disease is enhanced by high dose atorvastatin compared with combined low dose atorvastatin and ezetimibe results of the CEZAR study. Atherosclerosis. 2009;205:227–232
  35. Gokce N, Holbrook M, Hunter LM, Palmisano J, Vigalok E, Keaney JF, et al. Acute effects of vasoactive drug treatment on brachial artery reactivity. J Am Coll Cardiol. 2002;40:761–765

 Conflict of interest: Dr. Budoff is on the speaker's bureau for General Electric. The other authors report no conflicts of interest.

PII: S1934-5925(10)00008-0

doi: 10.1016/j.jcct.2010.01.007

Journal of Cardiovascular Computed Tomography
Volume 4, Issue 2 , Pages 119-126 , March 2010

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