Journal of Cardiovascular Computed Tomography
Volume 4, Issue 2 , Pages 127-135 , March 2010

Adenosine-stress dynamic myocardial volume perfusion imaging with second generation dual-source computed tomography: Concepts and first experiences

  • Gorka Bastarrika, MD, PhD

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, MSC 226, Charleston, SC 29401, USA
    • Department of Radiology, University of Navarra, Pamplona, Spain
  • ,
  • Luis Ramos-Duran, MD

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, MSC 226, Charleston, SC 29401, USA
  • ,
  • U. Joseph Schoepf, MD

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, MSC 226, Charleston, SC 29401, USA
    • Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC, USA
    • Corresponding Author InformationCorresponding author.
  • ,
  • Michael A. Rosenblum, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC, USA
  • ,
  • Joseph A. Abro, MA

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, MSC 226, Charleston, SC 29401, USA
  • ,
  • Robin L. Brothers, RT

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, MSC 226, Charleston, SC 29401, USA
  • ,
  • José L. Zubieta, MD, PhD

      Affiliations

    • Department of Radiology, University of Navarra, Pamplona, Spain
  • ,
  • Salvatore A. Chiaramida, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC, USA
  • ,
  • Doo Kyoung Kang, MD

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, MSC 226, Charleston, SC 29401, USA
    • Department of Radiology, Ajou University School of Medicine, Suwon, South Korea

Received 24 November 2009 ,Accepted 17 January 2010.

References 

  1. George RT, Jerosch-Herold M, Silva C, Kitagawa K, Bluemke DA, Lima JA, et al. Quantification of myocardial perfusion using dynamic 64-detector computed tomography. Invest Radiol. 2007;42:815–822
  2. George RT, Silva C, Cordeiro MA, DePaula A, Thompson DR, McCarthy WF, et al. Multidetector computed tomography myocardial perfusion imaging during adenosine stress. J Am Coll Cardiol. 2006;48:153–160
  3. George RT, Arbab-Zadeh A, Miller JM, Kitagawa K, Chang HJ, Bluemke DA, et al. Adenosine stress 64- and 256-row detector computed tomography angiography and perfusion imaging: a pilot study evaluating the transmural extent of perfusion abnormalities to predict atherosclerosis causing myocardial ischemia. Circ Cardiovasc Imaging. 2009;2:174–182
  4. Ruzsics B, Lee H, Zwerner PL, Gebregziabher M, Costello P, Schoepf UJ. Dual-energy CT of the heart for diagnosing coronary artery stenosis and myocardial ischemia-initial experience. Eur Radiol. 2008;18:2414–2424
  5. Ruzsics B, Schwarz F, Schoepf UJ, Lee YS, Bastarrika G, Chiaramida SA, et al. Comparison of dual-energy computed tomography of the heart with single photon emission computed tomography for assessment of coronary artery stenosis and of the myocardial blood supply. Am J Cardiol. 2009;104:318–326
  6. Lell M, Marwan M, Schepis T, Pflederer T, Anders K, Flohr T, et al. Prospectively ECG-triggered high-pitch spiral acquisition for coronary CT angiography using dual source CT: technique and initial experience. Eur Radiol. 2009;19:2576–2583
  7. Leschka S, Stolzmann P, Desbiolles L, Baumueller S, Goetti R, Schertler T, et al. Diagnostic accuracy of high-pitch dual-source CT for the assessment of coronary stenoses: first experience. Eur Radiol. 2009;19:2896–2903
  8. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. American Heart Association Writing Group of Myocardial Segmentation and Registration for Cardiac Imaging: Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002;105:539–542
  9. Plein S, Ryf S, Schwitter J, Radjenovic A, Boesiger P, Kozerke S. Dynamic contrast-enhanced myocardial perfusion MRI accelerated with k-t sense. Magn Reson Med. 2007;58:777–785
  10. Christian TF, Rettmann DW, Aletras AH, Liao SL, Taylor JL, Balaban RS, et al. Absolute myocardial perfusion in canines measured by using dual-bolus first-pass MR imaging. Radiology. 2004;232:677–684
  11. Nagel E, Klein C, Paetsch I, Hettwer S, Schnackenburg B, Wegscheider K, et al. Magnetic resonance perfusion measurements for the noninvasive detection of coronary artery disease. Circulation. 2003;108:432–437
  12. Blankstein R, Shturman LD, Rogers IS, Rocha-Filho JA, Okada DR, Sarwar A, et al. Adenosine-induced stress myocardial perfusion imaging using dual-source cardiac computed tomography. J Am Coll Cardiol. 2009;54:1072–1084
  13. Nikolaou K, Sanz J, Poon M, Wintersperger BJ, Ohnesorge B, Rius T, et al. Assessment of myocardial perfusion and viability from routine contrast-enhanced 16-detector-row computed tomography of the heart: preliminary results. Eur Radiol. 2005;15:864–871
  14. Mahnken AH, Bruners P, Katoh M, Wildberger JE, Gunther RW, Buecker A. Dynamic multi-section CT imaging in acute myocardial infarction: preliminary animal experience. Eur Radiol. 2006;16:746–752
  15. Dewey M, Zimmermann E, Deissenrieder F, Laule M, Dubel HP, Schlattmann P, et al. Noninvasive coronary angiography by 320-row computed tomography with lower radiation exposure and maintained diagnostic accuracy: comparison of results with cardiac catheterization in a head-to-head pilot investigation. Circulation. 2009;120:867–875
  16. Flohr TG, Bruder H, Stierstorfer K, Petersilka M, Schmidt B, McCollough CH. Image reconstruction and image quality evaluation for a dual source CT scanner. Med Phys. 2008;35:5882–5897
  17. Gerber BL, Belge B, Legros GJ, Lim P, Poncelet A, Pasquet A, et al. Characterization of acute and chronic myocardial infarcts by multidetector computed tomography: comparison with contrast-enhanced magnetic resonance. Circulation. 2006;113:823–833
  18. Stolzmann P, Scheffel H, Schertler T, Frauenfelder T, Leschka S, Husmann L, et al. Radiation dose estimates in dual-source computed tomography coronary angiography. Eur Radiol. 2008;18:592–599
  19. Gerber TC, Carr JJ, Arai AE, Dixon RL, Ferrari VA, Gomes AS, et al. Ionizing radiation in cardiac imaging: a science advisory from the American Heart Association Committee on Cardiac Imaging of the Council on Clinical Cardiology and Committee on Cardiovascular Imaging and Intervention of the Council on Cardiovascular Radiology and Intervention. Circulation. 2009;119:1056–1065
  20. Chang SM, Nabi F, Xu J, Raza U, Mahmarian JJ. Normal stress-only versus standard stress/rest myocardial perfusion imaging similar patient mortality with reduced radiation exposure. J Am Coll Cardiol. 2010;55:221–230
  21. Krittayaphong R, Boonyasirinant T, Saiviroonporn P, Nakyen S, Thanapiboonpol P, Yindeengam A, et al. Myocardial perfusion cardiac magnetic resonance for the diagnosis of coronary artery disease: do we need rest images?. Int J Cardiovasc Imaging. 2009;25(suppl 1):139–148

 Conflict of interest: G.B. is a consultant for General Electric, Medrad, and Siemens. U.J.S. is a consultant for and receives research support from Bayer-Schering, Bracco, General Electric, Medrad, and Siemens. The other authors have no conflict of interest to disclose.

PII: S1934-5925(10)00018-3

doi: 10.1016/j.jcct.2010.01.015

Journal of Cardiovascular Computed Tomography
Volume 4, Issue 2 , Pages 127-135 , March 2010