Periprocedural safety of 64-detector row coronary computed tomographic angiography: Results from the prospective multicenter ACCURACY trial

Bell, George W.; Edwardes, Michael; Dunning, Allison M.; Glasofer, Sidney; Lin, Fay Y.; Labounty, Troy M.; Delago, Augustin; Budoff, Matthew J.; Min, James K.

doi:10.1016/j.jcct.2010.08.003

« Previous Next »Journal of Cardiovascular Computed Tomography
Volume 4, Issue 6 , Pages 375-380, November 2010

Periprocedural safety of 64-detector row coronary computed tomographic angiography: Results from the prospective multicenter ACCURACY trial

George W. Bell, MD
- Department of Medicine, Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10128 and the New York Presbyterian Hospital, New York, NY
Michael Edwardes, PhD
- Everest Clinical Research Services, Ontario, Canada
Allison M. Dunning, MD
- Department of Public Health, Weill Medical College of Cornell University and the New York Presbyterian Hospital, New York, NY
- Department of Radiology, Weill Medical College of Cornell University and the New York Presbyterian Hospital, New York, NY
Sidney Glasofer, MD
- Department of Medicine, Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10128 and the New York Presbyterian Hospital, New York, NY
Fay Y. Lin, MD
- Department of Medicine, Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10128 and the New York Presbyterian Hospital, New York, NY
Troy M. Labounty, MD
- Department of Medicine, Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10128 and the New York Presbyterian Hospital, New York, NY
Augustin Delago, MD
- Capital Cardiology Associates, Albany, NY
Matthew J. Budoff, MD
- Department of Medicine, Harbor UCLA Medical Center, Los Angeles, CA
James K. Min, MD
- Department of Medicine, Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10128 and the New York Presbyterian Hospital, New York, NY
- Department of Radiology, Weill Medical College of Cornell University and the New York Presbyterian Hospital, New York, NY
- Corresponding author.

Received 6 March 2010; accepted 8 August 2010. published online 19 August 2010.

Background

Coronary computed tomographic angiography (CCTA) requires iodinated contrast and often atrioventricular nodal blocking agents and nitroglycerin for heart rate lowering and coronary vasodilation, respectively. To date, the periprocedural safety of CCTA is unknown.

Objectives

The purpose of this study was to evaluate the periprocedural safety of CCTA.

Methods

We prospectively evaluated 232 patients with symptomatic chest pain without preexisting renal insufficiency at 16 sites who underwent CCTA as part of the Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography (ACCURACY) trial. Patients received iodinated contrast, β-blockers, and nitroglycerin as part of a predefined CCTA protocol. We assessed the rates of adverse events (AEs) related to these agents.

Results

As measured by serum creatinine and creatinine clearance, no significant change was observed in renal function from baseline (1.00 ± 0.19 mg/dL; modification of diet in renal disease [MDRD]: 76.91 ± 17.96 mL/min/1.73 m²) to 48 hours (1.0 ± 0.2 mg/dL; P = 1.00; MDRD change: 0.2 ± 12.4 mL/min/1.73 m²; P = 0.83) or at 30 days (1.0 ± 0.2 mg/dL; P = 0.52; MDRD change: −0.9 ± 16.9 mL/min/1.73 m²; P = 0.77). Mean systolic blood pressure decreased from baseline (133 ± 19 mm Hg) at 1 hour (125 ± 17 mm Hg; P < 0.001) and rebounded at 48 hours (133 ± 17 mm Hg). Mean heart rate decreased from baseline (65 ± 10 beats/min) at 1 hour (60 ± 7 beats/min) but rose at 48 hours (69 ± 11 beats/min; P < 0.001. All patients were asymptomatic from baseline to follow-up.