Abstract
Background
Pericoronary adipose tissue (PCAT) attenuation is an indicator of active inflammation
of perivascular adipose tissue, which is supposed to increase in diabetic patients.
We aimed to investigate the PCAT attenuation values and high-risk plaque (HRP) features
in diabetic and non-diabetic subjects with different stenotic extents.
Methods
Consecutive type 2 diabetes patients and non-diabetic patients with chest pain and
intermediate pre-test probability of coronary artery disease (CAD) were prospectively
enrolled and underwent coronary computed tomography angiography (CCTA). At per-patient
level, PCAT attenuation values of three major epicardial coronary vessels, as well
as HRP features were measured. PCAT attenuation values and HRP features were compared
between diabetic and non-diabetic subjects according to the presence or absence of
obstructive stenosis.
Results
1700 patients (mean age: 65.5 ± 11.7, 940 males) were divided into two groups according
to presence of obstructive stenosis on CCTA. Propensity score matching was performed
in further analysis. RCAPCAT was significantly higher in diabetic subjects than that in non-diabetic subjects,
regardless of the presence of obstructive stenosis (−83.60 ± 9.51 HU vs. −88.58 ± 9.37
HU, p < 0.001) or absence of obstructive stenosis (−83.70 ± 10.32 HU vs. −88.76 ± 8.28
HU, p < 0.001). In contrast, HRP features were more commonly presented in diabetic
patients with obstructive stenosis than in those without obstructive stenosis. According
to subgroup analysis based on acquisition tube voltage, RCAPCAT was the only parameter showing consistent difference between diabetic and non-diabetic
patients.
Conclusions
RCAPCAT was significantly higher in diabetic patients than that in non-diabetic patients
regardless of stenotic severity and plaque vulnerability.
Keywords
Abbreviations:
CAD (coronary artery disease), CCTA (coronary computed tomography angiography), DM (diabetes mellitus), HRP (high-risk plaque), PCAT (pericoronary adipose tissue)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: January 25, 2022
Accepted:
January 22,
2022
Received in revised form:
January 21,
2022
Received:
September 21,
2021
Identification
Copyright
© 2022 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.
