Introduction: Myocardial work (MW) - the area of the myocardial stress-strain loop - can serve
as a better metric of myocardial performance than volumetric or strain measures, as
MW is independent of loading conditions and has been shown to reflect regional oxygen
perfusion and glucose metabolism. In practice, MW has been estimated as the ventricular
pressure-myocardial strain area (PSA) using echocardiography. However, the RV’s complex
geometry and echo’s limited acoustic windows can limit this approach. Therefore, we
seek to establish an alternative CT-based approach to map MW in the RV with high spatial
resolution. We demonstrate our approach in three populations: repaired tetralogy of
Fallot (rTOF) a right-heart-dominant disease, heart failure (HF) prior to LVAD implantation,
a biventricular disease, and chronic thromboembolic pulmonary hypertension (CTEPH),
a pulmonary vascular disease.
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© 2022 Published by Elsevier Inc.
